Luis Comolli

Personal homepage:
E-mail: lrcomolli AT

Department: Life Science Division, Lawrence Berkeley National Laboratory
Address: 1 Cyclotron Road, Berkeley, CA 94720

The driving motivation behind my research is to obtain three-dimensional, high resolution images with quantitative information. The aim is to obtain measurements and parameters, in addition to visual three-dimensional representations, which can inform on the fundamental biophysical laws underlying many biological processes. The main technique I use is cryogenic transmission electron microscopy (cryo-TEM) ideally in combination with light microscopy and other biophysical techniques, and with computer modeling and simulations. I use Single Particle (SP) methods to investigate questions at the molecular and macromolecular level, cryo-electron tomography (cryo-ET) for sub-cellular and whole cell research, and a combination of electron energy loss spectroscopy (EELS) and x-ray energy dispersive spectroscopy (XEDS) to investigate questions related to chemical composition within intact whole cells as well as nanoparticles-bacterial cells associations.


Allen, F. I., Comolli, L. R., Kusoglu, A., Modestino, M. A., Minor, A. M. Weber, A. Z., "he morphology of hydrated as-cast Nafion revealed through cryo electron tomography", ACS Macro Lett. doi:10.1021/mz500606h., Vol. 4, N. 1, pp. 1-5, 2015. - Link
Comolli, L. R., and Banfield, J. F., "Inter-species interconnections in acid mine drainage microbial communities", Front. Microbiol. doi:10.3389/fmicb.2014.00367, Vol. 5, N. 367, 2014. - Link
Comolli, L.R., Shin, S-H., Siegerist, C. E., Regan, W., Zettl, A., Bertozzi, C., and De Yoreo, J., "Conformational transitions at an S-layer growing boundary resolved by cryo-TEM", Angew. Chem. Int. Ed., 2013. - Link
Comolli, L.R., Shin, S-H., Tscheliessnig, R. Wang, C., Nam, K. T., Chung, S., Hexemer, A., Siegerist, C. E., De Yoreo, J., Bertozzi, C, "Self-Assembly of “S-Bilayers”, a Step Toward Expanding the Dimensionality of S-Layer Assemblies.", ACS Nano, 2013, in press. - Link
Jia Geng, Kyunghoon Kim, Jianfei Zhang, Artur Escalada, Ramya Tunuguntla , Luis R. Comolli , Frances I. Allen , Anna V. Shnyrova, Kang Rae Cho , Dayannara Munoz, Y. Morris Wang , Costas P. Grigoropoulos , Caroline M. Ajo-Franklin , Vadim A. Frolov, Aleksa, "Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes", Nature. doi:10.1038/nature13817, Vol. 514, pp. 612–615, 2014. - Link
Luef, B., Comolli, L. R., Frischkorn, K. R., Wrighton, K. C., and Banfield, J. F., "Diverse, uncultivated ultra-small bacterial cells in groundwater.", Nat. Comm., Vol. In Press, 2015. - Link
Madeo, D., Comolli, L. R., and Mocenni, C., "Emergence of microbial networks as a response to hostile environments.", Front. Microbiol. doi: 10.3389/fmicb.2014.00407, Vol. 5, N. 407, 2014. - Link

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